New inhibitors of histone deacetylase

摘要

Disclosed are compounds of the formula (I): the N-oxide forms, the pharmaceutically acceptable addition salts and the stereo-chemically isomeric forms thereof, wherein n is 0, 1, 2 or 3 and when n is 0 then a direct bond is intended; t is 0, 1, 2, 3 or 4 and when t is 0 then a direct bond is intended; each Q, X and Y is N or C where C singly bonded to two other atoms and doubly bonded to a third atom; each Z is N or CH where C is singly bonded to three other atoms R1 is -C(O)NH(OH); R2 is H, halo, hydroxy, amino, nitro, C1-6alkyl, C1-6alkoxy, trifluoromethyl, di(C1-6alkyl)amino, hydroxyamino or naphtalenylsulfonylpyrazinyl; -L- is a direct bond or a bivalent radical selected from C1-6alkanediyl, C1-6alkanediyloxy, amino, carbonyl or aminocarbonyl; each R3 independently represents a hydrogen atom and one hydrogen atom can be replaced by an aryl group; R4 is H, hydroxy, amino, hydroxyC1-6alkyl, C1-6alkyl, C1-6alkyloxy, arylC1-6alkyl aminocarbonyl, hydroxycarbonyl, aminoC1-6alkyl, aminocarbonylC1-6alkyl, hydroxycarbonylC1-6alkyl, hydroxyaminocarbonyl, C1-6alkyloxycarbonyl, C1- 6alkylaminocarbonyl, C1-6alkylaminoC1-6alkyl or di(C1-6alkyl)aminoC1-6alkyl. Further disclosed is the use of the compounds of the formula (I) in the preparation of a medicament for the treatment of proliferative diseases.