| 摘要 |
Disclosed is a host cell for recombinant expression of a F(ab')2 fragment, the host cell comprising adenovirus E1 sequences, and further comprising recombinant nucleic acid encoding a F(ab')2 fragment, functionally linked to one or more promoter and/or enhancer sequences. Also disclosed is a method of producing a F(ab')2 fragment, the method comprising: (a) providing a host cell comprising adenovirus E1 sequences, the host cell further comprising recombinant nucleic acid encoding a F(ab')2 fragment, and/or a precursor thereof, functionally linked to one or more promoter and/or enhancer sequences, (b) culturing the host cell, whereby the F(ab')2 fragment is secreted from the host cell.
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