| 摘要 |
Piperidine derivatives represented by the following general formula (I) and non-toxic salts thereof are described. Because these derivatives have PDE4 inhibitory activity, the compounds represented by the general formula (I) are useful in preventing and/or treating conditions such as inflammatory diseases, diabetic diseases, allergic diseases, autoimmune diseases, osteoporosis, obesity, depression, Parkinson's disease, ischemic reperfusion failure and leukaemia. In formula 1 R1represents 1) a hydrogen atom or 2) a cyano group; R2 and R3 each independently represents 1) a C1-8 alkyl group, 2) a C3-7 cycloalkyl group, 3) a C1-8 alkyl group substituted with a C3-7 cycloalkyl group, 4) a C1-8 alkyl group substituted with 1 to 3 halogen atom(s), 5) a hydrogen atom, 6) a C1-8 alkyl group substituted with a phenyl group, 7) a C1-8 alkyl group substituted with a C1-8 alkoxy group; R4 and R5 each independently represents 1) a hydrogen atom or 2) a C1-8 alkyl group, or R4 and R5 are taken together with the binding carbon atom to represent a C3-7 saturated carbocyclic ring; R6 represents 1) a hydroxyl group, 2) a C1-8 alkoxy group, 3) -NHOH, or 4) a C1-8 alkoxy group substituted with a phenyl group; and m is 0 or an integer of 1 to 4.
|
