| 摘要 |
The present invention relates to fatty acid analogues of the general formula I: R<SUB>1</SUB>-[x<SUB>i</SUB>-CH<SUB>2</SUB>]<SUB>n</SUB>-COOR<SUB>2</SUB>; wherein R<SUB>1 </SUB>is; a C<SUB>1</SUB>-C<SUB>24 </SUB>alkene with one or more double bonds and/or with one or more triple bonds, and/or, a C<SUB>1</SUB>-C<SUB>24 </SUB>alkyne, and/or, a C<SUB>1-C</SUB><SUB><SUB2>4</SUB2></SUB><SUB>24 </SUB>alkyl, or a C<SUB>1</SUB>-C<SUB>24 </SUB>alkyl substituted in one or several positions with one or more compounds selected from the group comprising fluoride, chloride, hydroxy, C<SUB>1</SUB>-C<SUB>4 </SUB>alkoxy, C<SUB>1</SUB>-C<SUB>4 </SUB>alkylthio, C<SUB>2</SUB>-C<SUB>5 </SUB>acyloxy or C<SUB>1</SUB>-C<SUB>4 </SUB>alkyl, and; wherein R2 represents hydrogen or C<SUB>1</SUB>-C<SUB>4 </SUB>alkyl, and; wherein n is an integer from 1 to 12, and; wherein i is an old number and indicates the position relative to COOR<SUB>2</SUB>, and; wherein X<SUB>i </SUB>independent of each other are selected from the group comprising, O, S, SO, SO<SUB>2</SUB>, Se and CH<SUB>2</SUB>, and; with the proviso that at least one of the X<SUB>i </SUB>is not CH<SUB>2</SUB>; which can be used for the treatment and/or prevention of inflammatory disorders. Further, the invention relates to methods for enhancing the endogenous production of interleukin-10 (IL-10) and suppressing the production of interleukin-2 in mammalian cells or tissues. The invention also relates to a method for inhibiting the proliferation of stimulated peripheral mononuclear cells.
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