COMPOUNDS USEFUL IN THERAPY

摘要

Compounds of formula (I), or a pharmaceutically acceptable derivative thereof, wherein: X represents NR or O; R represents hydrogen, C1-8 alkyl or SO2[C,1-8 alkyl]; W represents N or CH; Y and Y' independently represent hydrogen, halogen, OH, CF3, OCF3, CN, NH2 C1-8 alkyl, C1-8 alkyloxy or C3-8cycloalkyl; Ring A represents a heterocyclic ring containing at least one nitrogen atom; Z represents a direct link, C1-8 alkyl or C3-8 cycloalkyl; R<1> represents R<2>, OR<2>, OR <3>-R<4>, N(R<2>)[C1-8 alkylene]aR<4>; NCOR<2>, or SR<4>; R<2> and R<4> independently represent hydrogen, C3-8 cycloalkyl, CF3, Ar or Het; R<3> represents a direct link or C1-8 alkyl; is 0 or 1; Ar represents an aromatic ring, optionally fused to a heterocyclic ring, and/or optionally substituted with one or more groups as described below; Het represents a heterocyclic ring optionally substituted with one or more groups as described below, and/or optionally fused to an aromatic ring which is optionally substituted with one or more groups as described below; at each occurrence C1-8alkyl, C1-8alkylene and C3-8cycloalkyl may be independently optionally substituted with one or more groups as described below; substituent groups for Ar, Het, C1-8alkyl, C1-8alkylene and C3-8cycloalkyl referred to the above are independently selected from hydrogen, halogen, C1-8alkyl, C1-8alkyloxy, S[C1-8alkyl], CN, CF3, NH2 and OH; are useful for treating anxiety, cardiovascular disease (including angina, atherosclerosis, hypertension, heart failure, edema, hypernatremia), dysmenorrhoea (primary and secondary), endometriosis, emesis (including motion sickness), intrauterine growth retardation, inflammation (including rheumatoid arthritis), mittelschmerz, preclampsia, premature ejaculation, premature (preterm) labor and Raynaud's disease.