发明名称 |
POLYMERIC IMPLANTS, PREFERABLY CONTAINING A MIXTURE OF PEG AND PLG, FOR CONTROLLED RELEASE OF ACTIVE AGENTS, PREFERABLY A GNRH |
摘要 |
<p>Polymeric devices for controlled release of an active agent of interest are provided. The active agent is provided within a biodegradable polymer system to supply a polymeric device for controlled release of the active agent. The polymer system is a copolymer or a polymer blend comprising a hydrophobic component and a hydrophilic component, and the polymer system does not form a hydrogel when contacted with, or immersed in an aqueous system, for example when the device is implanted in a subject. When the device is administered to a subject, for example, when it is implanted, the device releases the active agent in a controlled fashion without a lag period, or with a minimal lag period. Methods for producing the polymeric devices are also provided, as are methods of using the polymeric devices to provide for controlled release of an active agent in a subject. Preferred hydrophobic component is a PLG. Preferred hydrophilic Components are a PEG or a methoxyPEG. Preferred peptides are LHRH, goserelin, leuprolide.</p> |
申请公布号 |
WO2005067889(A1) |
申请公布日期 |
2005.07.28 |
申请号 |
WO2004US43389 |
申请日期 |
2004.12.23 |
申请人 |
DURECT CORPORATION;GIBSON, JOHN, W.;TIPTON, ARTHUR, J. |
发明人 |
GIBSON, JOHN, W.;TIPTON, ARTHUR, J. |
分类号 |
A61K9/00;A61K9/16;A61K9/20;A61K38/09;A61K38/24;(IPC1-7):A61K9/00;A61K38/00 |
主分类号 |
A61K9/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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