PARTICLE-INDUCED GHRELIN IMMUNE RESPONSE

摘要

The present invention is related to the fields of molecular biology, virolog y, immunology and medicine. The invention provides a modified virus-like partic le (VLP) comprising a VLP and particular peptides derived from ghrelin linked thereto. The invention also provides a process for producing the modified VL P. The modified VLPs of the invention are useful in the production of vaccines for the treatment of obesity and other disease associated with increased foo d- uptake or increased body weight and to efficiently induce immune responses, in particular antibody responses. Furthermore, the compositions of the inventio n are particularly useful to efficiently induce self-specific immune responses within the indicated context.