发明名称 |
VERFAHREN ZUR HERSTELLUNG VON SUBSTANZ GM-95 |
摘要 |
<p>A method of manufacturing substance GM-95 having general formula ÄIÜ, comprising (a) deprotect ing a macrocyclic compound having general formula ÄIIÜ (wherein, R<1>'s are the same or different and each represents a lower alkyl group, and R<2> represents a thiol protecting group) by removing acetal protecting groups (the R<1'>s) thereof, and forming an oxazole ring through an intramolecular cyclization reaction between produced formyl group and an amide group, and (b) deprotecting a resulting macrocyclic compound having general formula ÄIIIÜ (wherein, R<2> is as mentioned above) by removing the thiol protecting group (R<2>) thereof, and forming a thiazoline ring through an intramolecular cyclization reaction between a thiol group thus produced and an amide group.</p> |
申请公布号 |
DE60111651(D1) |
申请公布日期 |
2005.07.28 |
申请号 |
DE2001611651 |
申请日期 |
2001.12.12 |
申请人 |
SOSEI CO., LTD. |
发明人 |
YAMADA, SHOZO;SHIGENO, KAZUHIKO;KITAGAWA, KAZUHIRO;OKAJIMA, SHIGEO;ASAO, TETSUJI |
分类号 |
A61P35/00;C07D498/22;C07D513/22;(IPC1-7):C07D513/22;C07D263/34;A61K31/429 |
主分类号 |
A61P35/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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