发明名称 |
POLYOL-IFN-BETHA CONJUGATES |
摘要 |
PEG-IFN- beta conjugates, where a PEG moiety is covalently bound to Cys<17> of human IFN- beta , are produced by a process of site specific PEGylation with a thiol reactive PEGylating agent. A pharmaceutical composition and a method for treating infections, tumors and autoimmune and inflammatory diseases are also provided. The invention further relates to a method for the stepwise attachment of PEG moieties in series to a polypeptide, and more particularly to IFN- beta .
|
申请公布号 |
HU0300548(A3) |
申请公布日期 |
2005.07.28 |
申请号 |
HU20030000548 |
申请日期 |
1999.04.28 |
申请人 |
APPLIED RESEARCH SYSTEMS ARS HOLDING N.V., WILLEMSTAD/CURACAO, HOLLAND ANTILLAK |
发明人 |
|
分类号 |
A61K47/34;A61K38/21;A61K47/48;A61P31/00;A61P35/00;A61P37/06;A61P39/00 |
主分类号 |
A61K47/34 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|