POLYMORPHISMS OF CHROMOSOME 9 IMPLICATED IN PREMATURE CANITIES

摘要

The invention relates to the use of at least one of the 4 SNP markers rs306534, rs3739902, rs575916 and rs365297 for carrying out a diagnosis, a process for diagnosing a predisposition to premature canities, the use of a means for determining the alleles of the 4 markers with a view to a diagnosis and a kit for the diagnosis, a process for the diagnosis of a predisposition to premature canities based on the haplotype defined by the markers rs3739902, rs2583805 and rs377090 and the use of at least one polynucleotide fragment comprising at least 18 consecutive nucleotides, the sequence of which corresponds to all or part of the region in a non-human mammal homologous to that of the human chromosome 9 defined by the SNP markers rs306534 and rs365297 for the diagnosis of a predisposition to premature canities in said mammal.