METHOD FOR PRODUCING RACEMIC OCTAHYDROBISISOQUINOLINE, METHOD FOR PRODUCING OPTICALLY ACTIVE OCTAHYDROBISISOQUINOLINE AND OPTICALLY ACTIVE OCTAHYDROBISISOQUINOLINE

摘要

PROBLEM TO BE SOLVED: To provide a synthetic method for predominantly producing racemic octahydrobisisoquinoline, a method for optically resolving the racemic isomer to obtain (+)- or (-)-octahydrobisisoquinoline, and provide the resultant (+)- or (-)-octahydrobisisoquinoline. SOLUTION: Dihydroisoquinoline is dimerized to obtain octahydrobisisoquinoline wherein a niobium salt is used as a reaction accelerator. COPYRIGHT: (C)2005,JPO&NCIPI