发明名称 |
Process for the preparation of amorphous atorvastatin calcium |
摘要 |
A process for the preparation of amorphous atorvastatin calcium and hydrates thereof, which comprises: (a) hydrolysis of the precursor lactone using sodium hydroxide to form atorvastatin sodium salt solution; (b) addition of the atorvastatin sodium salt solution to a calcium chloride or calcium acetate solution in the absence or presence of seeds of amorphous atorvastatin calcium; and (c) isolation of the resultant amorphous atorvastatin calcium salt by filtration and drying.
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申请公布号 |
US2005165242(A1) |
申请公布日期 |
2005.07.28 |
申请号 |
US20040771383 |
申请日期 |
2004.02.05 |
申请人 |
APOTEX PHARMACHEM INC. |
发明人 |
CHE DAQING;KINSMAN AARON C.;GUNTOORI BHASKAR R.;MURTHY K.S. K. |
分类号 |
A61K31/40;A61P3/06;C07D207/34;C07D405/06;(IPC1-7):C07D27/333 |
主分类号 |
A61K31/40 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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