发明名称 THE USE OF SUBSTITUTED CYANOPYRROLIDINES AND COMBINATION PREPARATIONS CONTAINING THEM FOR TREATING HYPERLIPIDEMIA AND ASSOCIATED DISEASES
摘要 Disclosed are methods and compositions for the treatment of hyperlipidemia and conditions associated therewith, such as CHD, ischemic stroke, restenosis after angioplasty, peripheral vascular disease, intermittent claudication, myocardial infarction (e.g. necrosis and apoptosis), dyslipidemia and post-prandial lipemia. The methods include administration of a therapeutically effective amount of a compound of formula I wherein R is substituted adamantyl; and N is 0 to 3; in free form or in acid addition salt form, and a pharmaceutically acceptable carrier.
申请公布号 ZA200409136(B) 申请公布日期 2005.07.27
申请号 ZA20040009136 申请日期 2004.11.11
申请人 NOVARTIS AG 发明人 Thomas Edward HUGHES;David Greenville HOLMES
分类号 A61K;C07D207/16;A61K31/015;A61K31/05;A61K31/20;A61K31/22;A61K31/355;A61K31/366;A61K31/375;A61K31/40;A61K31/401;A61K31/405;A61K31/4415;A61K31/455;A61K31/616;A61K31/714;A61K45/00;A61K45/06;A61P;A61P3/06;A61P9/10 主分类号 A61K
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