发明名称 |
HERBAL EXTRACT COMPRISING A MIXTURE OF SAPONINS OBTAINED FROM SAPINDUS TRIFOLIATUS FOR ANTICONVULSANT ACTIVITY |
摘要 |
<p>A pharmaceutical composition comprising a herbal extract, comprising a mixture of saponins prepared from the pericarp of Sapindus trifoliatus, with binding affinities for the receptor sites viz. GABA-A agonist site, Glutamate-AMPA site, Glutamate-Kainate site, Glutamate-NMDA agonistic site, Glutamate-NMDA glycine (strychnine insensitive) site and Sodium channel (site 2), having major mediatory role in anticonvulsant activity. A process for preparation of the herbal extract; isolation of six pure compounds from the mixture of saponins in the aqueous extract; and a pharmaceutical composition comprising the said extract in combination with pharmaceutically acceptable additives. A method of prophylactic treatment of migraine through anticonvulsant activity of the composition by its administration through intranasal route.</p> |
申请公布号 |
EP1556062(A2) |
申请公布日期 |
2005.07.27 |
申请号 |
EP20030791169 |
申请日期 |
2003.08.27 |
申请人 |
LUPIN LIMITED |
发明人 |
ARORA, SUDERSHAN KUMAR;SRIVASTAVA, VANDITA;ADDEPALLI, VEERANJANEYULU;NATESAN, SRIDHAR;GOEL, RAJAN |
分类号 |
A61K;A61K31/704;A61K35/00;A61K36/77;A61P;A61P25/06;(IPC1-7):A61K35/00 |
主分类号 |
A61K |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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