Antagonists of melanin concentrating hormone receptor

摘要

This invention provides compounds that are antagonists of melanin concentrating hormone receptor-1 (MCH-R1). The compounds are represented by formula I: where m is zero or one, n is zero to two, Y is oxygen or -N(R⁹)-, R¹, R², R³, R⁴, R⁵, R⁹ and Ring A are defined in the specification. Coumarin and quinolone compounds where R¹ and R² together form a fused benzo ring are preferred. The invention also provides compounds of formula VI where the coumarin moiety is replaced by a quinazolinone ring. The compounds are useful for treating MCH-R1-related disorders, particularly overweight conditions including obesity.