发明名称 |
Prophylactic and therapeutic immunization against protozoan infection and disease |
摘要 |
Polypeptide and polynucleotide vaccines effective to treat or prevent infection of a mammal, such as a dog, a cat, or a human, by a protozoan. Methods of treatment and prevention are also provided, including therapeutic administration of the vaccine to an infected mammal to prevent progression of infection to a chronic debilitating disease state. Preferred embodiments of the polynucleotide vaccine contain nucleotide coding regions that encode polypeptides that are surface-associated or secreted by T. cruzi. Optionally the efficacy of the polynucleotide vaccine is increased by inclusion of a nucleotide coding region encoding a cytokine. Preferred embodiments of the polypeptide vaccine include immunogenic peptides that contain membrane transducing sequences that allow the polypeptides to translocate across a mammalian cell membrane.
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申请公布号 |
US2005158347(A1) |
申请公布日期 |
2005.07.21 |
申请号 |
US20040015578 |
申请日期 |
2004.12.17 |
申请人 |
THE UNIVERSITY OF GEORGIA RESEARCH FOUNDATION, INC. |
发明人 |
TARLETON RICK L.;GARG NISHA |
分类号 |
A61K39/005;(IPC1-7):A61K39/002;A61K39/008 |
主分类号 |
A61K39/005 |
代理机构 |
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