Pyrrolidinyl, piperidinyl or homopiperidinyl substituted (benzodioxan, benzofuran or benzopyran) derivatives

摘要

The present invention concerns compounds of formula (I) a stereochemically isomeric form thereof, an N-oxide form thereof or a pharmaceutically acceptable acid addition salt thereof, wherein -Z¹-Z²- is a bivalent radical; R¹, R² and R³ are each independently selected from hydrogen, C_1-6alkyl, hydroxy, halo and the like; or when R¹ and R² are on adjacent carbon atoms, R¹ and R² taken together may form a bivalent radical of formula; Alk is optionally substituted C_1-6alkanediyl; the bivalent radical is a substituted piperidinyl, an optionally substituted pyrrolidinyl, homopiperidinyl, piperazinyl or tropyl; R⁵ is a radical of formula wherein n is 1 or 2; p¹ is 0, and p² is 1 or 2; or p¹ is 1 or 2, and p² is 0; X is oxygen, sulfur or -NR⁹; Y is oxygen or sulfur; R⁷ is hydrogen, C_1-6alkyl, C_3-6cycloalkyl, phenyl or phenylmethyl; R⁸ is C_1-6alkyl, C_3-6cycloalkyl phenyl or phenylmethyl; R⁹ is cyano, C_1-6alkyl, C_3-6cyclo-alkyl, C_1-6alkyloxycarbonyl or aminocarbonyl; R¹⁰ is hydrogen or C_1-6alkyl; and Q is a bivalent radical. Processes for preparing said products, formulations comprising said products and their use as a medicine are disclosed, in particular for treating conditions which are related to impaired fundic relaxation.