| 摘要 |
Compounds of formula (I) or (II) , or pharmaceutically acceptable salts, esters, amides, or prodrugs thereof, wherein: A and G are each independently N or N<+>-O<->; m and n are each independently 0, 1, or 2; X<1> and X<3> are each independently O, S, and -N(R<1>)-; X<2> is O, S, -N(R<1>)-, -N(Ar<2>)-, and -N(R<2>)C(O)-; Ar<1> is a six-membered aromatic ring; Ar<2> is cyclohexyl or a mono- or bicyclic aromatic ring, and R<13> is hydrogen, alkyl, or halogen, as defined herein. The compounds are useful in treating conditions or disorders prevented by or ameliorated by nAChR ligands. Also disclosed are pharmaceutical compositions having compounds of formulas (I) and (II) and methods for using such compounds and compositions. |
