CATHEPSIN CYSTEINE PROTEASE INHIBITORS

摘要

The present invention relates to a novel class of compounds mainly, substituted leucinamide-carboxylate derivatives of formula (I) wherein X is O or NR<9>, Y is CR<1>R<2>, -SO<2>, C=O or NR<9>; Z is CR<1>R<2>, O, S, -SO2 or NR<9> and each G is independently a CR<1>CR<2> and pharmaceutical compositions thereof. Said compounds are cathepsin cysteine protease inhibitors, including but not limited to, inhibitors of cathepsin K, L, S and B. These compounds are useful for treating and preventing cathpesin dependent conditions in which inhibition of bone resorption is indicated, such as osteoporosis.