| 摘要 |
A process for the preparation of a compound of Formula (I) and intermediates useful therein are provided. The process comprises reacting a compound of formula R<1>-CO-CH2-E with a compound of formula R<2>-CHX<1>X<2> in the presence of a compound of formula R<3>R<4>N-C(=NH)NH2 and a catalyst, thereby to form a dihydropyrimidine; and oxidising the dihydropyrimidine to form the compound of Formula (I). R<1> is H or an alkyl group; R<2> is H, an alkyl or aryl group; R<3> and R<4> are each independently H, alkyl or aryl, or R<3> and R<4> are linked to form, together with the nitrogen to which they are attached to form a 5 to 7 membered heterocyclic ring; E is H, an unsubstituted alkyl group, an aryl group or an electron withdrawing group; and X<1> and X<2> are each independently leaving groups, or X<1> and X<2> together represent =O.
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