BIS-PYRIDINO CONTAINING COMPOUNDS FOR USE IN THE TREATMENT OF CNS PATHOLOGIES
摘要
N-n-Alkylation of nicotine converts nicotine from an agonist into an antagonist specifically for neuronal nicotinic acetylcholine receptor subtypes mediating nicotine-evoked dopamine release. Conformationally restricted analogs exhibit both high affinity and selectivity at this site, and are able to access the brain due to their ability to act as substrates for the blood-brain barrier choline transporter.
申请公布号
WO2005066129(A2)
申请公布日期
2005.07.21
申请号
WO2005US00139
申请日期
2005.01.03
申请人
UNIVERSITY OF KENTUCKY RESEARCH FOUNDATION;CROOKS, PETER, A.;DWOSKIN, LINDA, P.;AYERS, JOSHUA, T.;GRINEVICH, VLADIMIR;SUMITHRAN, SAGEETHA, P.
发明人
CROOKS, PETER, A.;DWOSKIN, LINDA, P.;AYERS, JOSHUA, T.;GRINEVICH, VLADIMIR;SUMITHRAN, SAGEETHA, P.