| 摘要 |
A method of identifying a compound that inhibits the sumoylation of Tcf-4 by proteins of the PIAS (protein inhibitor of activated STAT) (for example, PIASy, PIAS1, PIAS3 or PIASxalpha) is described. Also provided are compounds identified by this method; inhibitors for sumoylation of Tcf-4 by the PFAS family proteins and Tcf-4 desumoylation agents; inhibitors of transcriptional activity of Tcf-4 comprising the above-described inhibitors and/or desumoylation agents; preventives and/or remedies for colon cancer comprising the above-described inhibitors and/or desumoylation agents or the transcriptional activity inhibitors; a method of inhibiting the transcriptional activity of Tcf-4 characterized by inhibiting the sumoylation of Tcf-4 by the PIAS family protein and/or desumoylating sumoylated Tcf-4; and a method of preventing and/or treating colon cancer.
|
