A diabetes type 2 model laboratory animal is disclosed which comprises cells over-expressing GPR40 under the control of the Ipf1/Pdx1 promoter. Also disclosed is the use of the model animal for the identification of agonists or antagonists towards GPR40, useful for the development of pharmaceuticals towards treatment of the disease.
申请公布号
WO2005015990(A8)
申请公布日期
2005.07.21
申请号
WO2004SE01209
申请日期
2004.08.18
申请人
BETAGENON AB;YEDA RESEARCH AND DEVELOPMENT CO LTD;EDLUND, HELENA;WALKER, MICHAEL D.;RUBINS, NIR;STENEBERG, PAER
发明人
EDLUND, HELENA;WALKER, MICHAEL D.;RUBINS, NIR;STENEBERG, PAER