发明名称 |
Fusion polypeptides capable of activating receptors |
摘要 |
A fusion polypeptide comprising (A)<SUB>x</SUB>-M-(A')<SUB>y</SUB>, wherein A and A' are each polypeptides capable of binding a target receptor. The fusion polypeptides of the invention form multimeric proteins which activate the target receptor. A and A' may be each be an antibody or fragment derived from an antibody specific for a target receptor, such as the same or different ScFv fragmetns, and/or a ligand or ligand fragment or derivative capable of binding the target protein, M is a multimerizing component, and X and Y are independently a number between 1-10. |
申请公布号 |
US2005158829(A1) |
申请公布日期 |
2005.07.21 |
申请号 |
US20050035599 |
申请日期 |
2005.01.14 |
申请人 |
FANDL JAMES P.;CHEN GANG;PAPADOPOULOS NICHOLAS;ALDRICH THOMAS H. |
发明人 |
FANDL JAMES P.;CHEN GANG;PAPADOPOULOS NICHOLAS;ALDRICH THOMAS H. |
分类号 |
C07H21/04;C07K14/515;C07K16/28;(IPC1-7):C07H21/04;C12N5/06 |
主分类号 |
C07H21/04 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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