TNF ANTAGONISTS AND TNF INHIBITORS COMPRISING THE SAME AS THE ACTIVE INGREDIENT

摘要

It is intended to provide tumor necrosis factor mutant proteins, in particular, tumor necrosis factor mutant proteins specific for TNF-R1 or TNF-R2, and tumor necrosis factor inhibitors or tumor necrosis factor preparations comprising the same as the active ingredient. This object can be achieved by providing a tumor necrosis factor mutant protein having an amino acid sequence derived from the amino acid sequence represented by SEQ ID NO:1 in Sequence Listing by the substitution of one or more amino acid residues at the 29-, 31-, 32-, 145-, 146- and 147-positions (counted from the N-end) and the amino acid residues at the 84- to 89-positions by other amino acid residue(s) and a tumor necrosis factor inhibitor or a tumor necrosis factor preparation comprising the same as the active ingredient.