发明名称 |
FORMULATIONS OF HYDROPHOBIC PROTEINS IN AN IMMUNOGENIC COMPOSITION HAVING IMPROVED TOLERABILITY |
摘要 |
<p>The present invention provides a method for producing a less-painful immunogenic composition of a hydrophobic protein in a pharmaceutically acceptable carrier suitable for administering to a mammal, comprising the steps of (a) solubilizing said hydrophobic protein with a zwitterionic detergent to make a first composition; (b) altering said first composition, such that the altered composition produces a reduction in pain as measured i n the rat footpad model as compared to said first composition.</p> |
申请公布号 |
CA2551896(A1) |
申请公布日期 |
2005.07.21 |
申请号 |
CA20042551896 |
申请日期 |
2004.12.28 |
申请人 |
WYETH |
发明人 |
HAGEN, MICHAEL;MATSUKA, YURY VLADIMIROVICH;HOISETH, SUSAN KAY;METCALF, THOMAS NEWELL III |
分类号 |
A61K39/095;A61K47/18;A61P43/00 |
主分类号 |
A61K39/095 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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