| 摘要 |
The present invention relates to a novel class of compounds mainly, substituted leucinamide-carboxylate derivatives of formula (I) wherein X is O or NR9, Y is CR1R2, -SO2, C=O or NR9; Z is CR1R2, O, S, -SO2 or NR9 and each G is independently a CR1CR2 and pharmaceutical compositions thereof. Said compounds are cathepsin cysteine protease inhibitors, including but not limited to, inhibitors of cathepsin K, L, S and B. These compounds are usefu l for treating and preventing cathpesin dependent conditions in which inhibiti on of bone resorption is indicated, such as osteoporosis.
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