| 摘要 |
Aspects of the present invention are directed towards compounds of Formula I for the treatment of human erectile disorders including erectile dysfunction in men. wherein: R<SUB>1 </SUB>is hydrogen, halo, hydroxy, nitro, cyano, phenyl, trifluoromethyl, C<SUB>1</SUB>-C<SUB>6 </SUB>alkyl, C<SUB>1</SUB>-C<SUB>6 </SUB>alkoxy, carboxy, amino, cyclohexyl, C<SUB>1</SUB>-C<SUB>6 </SUB>alkylamino, or (C<SUB>1</SUB>-C<SUB>6 </SUB>alkyl)<SUB>2</SUB>amino; R<SUB>2 </SUB>is hydrogen, halo, hydroxy, nitro, cyano, trifluoromethyl, C<SUB>1</SUB>-C<SUB>6 </SUB>alkyl, C<SUB>1</SUB>-C<SUB>6 </SUB>alkoxy, carboxy, amino, C<SUB>1</SUB>-C<SUB>6 </SUB>alkylamino, or (C<SUB>1</SUB>-C<SUB>6 </SUB>alkyl)<SUB>2</SUB>amino; R<SUB>3 </SUB>is a group of the formula R<SUB>4 </SUB>is hydrogen or C<SUB>1</SUB>-C<SUB>6 </SUB>alkyl; R<SUB>5 </SUB>is hydrogen, halo, hydroxy, nitro, cyano, phenyl, trifluoromethyl, C<SUB>1</SUB>-C<SUB>6 </SUB>alkyl, C<SUB>1</SUB>-C<SUB>6 </SUB>alkoxy, carboxy, amino, C<SUB>1</SUB>-C<SUB>6 </SUB>alkylamino, or (C<SUB>1</SUB>-C<SUB>6 </SUB>alkyl)<SUB>2</SUB>amino; and R<SUB>6 </SUB>is hydrogen, halo, hydroxy, nitro, cyano, trifluoromethyl, C<SUB>1</SUB>-C<SUB>6 </SUB>alkyl, C<SUB>1</SUB>-C<SUB>6 </SUB>alkoxy, carboxy, amino, C<SUB>1</SUB>-C<SUB>6 </SUB>alkylamino, or (C<SUB>1</SUB>-C<SUB>6 </SUB>alkyl)<SUB>2</SUB>amino; or pharmaceutically acceptable salts thereof.
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