NOVEL 2-HETEROARYL-SUBSTITUTED BENZIMIDAZOLE DERIVATIVE

摘要

A glucokinase activator; a therapeutic and/or preventive agent for diabetes or a therapeutic and/or preventive agent for complications of diabetes, such as retinopathy, nephropathy, neurosis, ischemic heart disease, and arteriosclerosis; and a therapeutic and/or preventive agent for obesity. The glucokinase activator is characterized by containing either a 2-heteroaryl-substituted benzimidazole derivative represented by the general formula (I-0): 1 RING A (I-0) [wherein X represents carbon or nitrogen; X1, X2, X3, and X4 each independently represents carbon or nitrogen; ring A represents, e.g., a 5- or 6-membered nitrogenous aromatic heterocycle represented by the formula (II): 1 RING A (II) (wherein X represents carbon or nitrogen); R<1> represents aryl, etc.; R<2> represents hydroxy, etc.; R<3> represents -(C1-6 alkyl), etc.; R<4> represents -(C1-6 alkyl), etc.; X5 represents -O-, etc.; a is 1, 2, or 3; q is an integer of 0 to 2; and m is an integer of 0 to 2] or a pharmaceutically acceptable salt of the derivative.