ANTIBODIES AGAINST THE AMINO TERMINUS REGION OF CIRCUMSPOROZOITE PROTEIN PREVENT THE ONSET OF MALARIA INFECTION

摘要

The present invention relates to a polypeptide comprising a sequence as shown as the Peptide P6-identified epitope domain from amino acid 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49, 50, 51, 52, 53, 54, 55, 56, 57, 58, 59, 60, 61, 62, 63, 64, 65, 66, 67, 68, 69, 70, 71, 72, 73, 74, 75, 76, 77, 78, 79, 80, 81, 82, 83, 84, 85, 86, 87, 88, 89, 90, 91, 92, or 93 - 113, 114, 115, 116, or 117 of the Circumsporozoite protein, or allelic variant, functional equivalent, derivative, homologue, or analogue thereof, that reacts with antibodies that inhibit liver cell invasion by P. falciparum, substantially in isolation from sequences naturally occurring adjacent thereto in the Circumsporozoite protein.