AMIDE DERIVATIVE AND MEDICINE

摘要

An amide derivative or salt thereof which has excellent BCR-ABL tyrosin kina se inhibitory activity. The amide derivative is represented by the following general formula [1]: [1] [6] (wherein R1 represents -CH2-R11 (R11 represents a nitrogenous saturated heterocyclic group), etc.; R2 represents alkyl, halogeno, haloalkyl, etc.; R3 represents hydrogen, etc.; Het1 represents the group represented by the chemical formula [6] shown above, etc.; and Het2 represents pyrimidinyl, etc.). Also provided is a medicinal composition containing the amide derivative or salt as an active ingredient. The compoun ds are useful as a BCR-ABL tyrosin kinase inhibitor.