CORONA-VIRUS-LIKE PARTICLES COMPRISING FUNCTIONALLY DELETED GENOMES

摘要

The invention relates to the field of coronaviruses and diagnosis, therapeutic use and vaccines derived thereof. Methods are shown for at least in part inhibiting anti-parallel coiled coil formation of a coronavirus spike protein comprising decreasing the contact between heptad repeat regions of said protein. The invention provides a peptide comprising a heptad repeat region of a corona viral spike protein and/or a functional fragment and/or an derivative thereof. The invention also provides antibodies and compounds inhibiting corona viral infection of cells, and/or cell-to-cell fusion. The invention also discloses heptad repeat regions and a fusion peptide of SARS-CoV.