METHODS FOR RECOVERING CLEAVED PEPTIDE FROM A SUPPORT
摘要
Methods for the solid phase synthesis of peptides and peptide intermediates, in particular methods involving recovering peptides from resin supports at excellent yield. In this invention, an alternating at least partially repeating cycle of shrinking and swelling treatments are used. Each shrinking or swelling part of a cycle may involve one or more washes. The process provides excellent recovery of peptide in a very efficient manner in terms of the number of individual washes and the total volume of wash reagents used.
申请公布号
WO2005063792(A2)
申请公布日期
2005.07.14
申请号
WO2004EP14601
申请日期
2004.12.22
申请人
F. HOFFMANN-LA ROCHE AG;BIGELOW, ROGER, D.;CAIN, ROBERT, O.