| 发明名称 |
Substituted 3-aryl-5-aryl-[1,2,4]-oxadiazoles and analogs as activators of caspases and inducers of apoptosis and the use thereof |
| 摘要 |
The present invention is directed to substituted 3-aryl-5-aryl-[1,2,4]-oxadiazoles and analogs thereof, represented by the Formula I: wherein Ar<SUB>1</SUB>, Ar<SUB>3</SUB>, A, B and D are defined herein. The present invention also relates to the discovery that compounds having Formula I are activators of caspases and inducers of apoptosis. Therefore, the activators of caspases and inducers of apoptosis of this invention may be used to induce cell death in a variety of clinical conditions in which uncontrolled growth and spread of abnormal cells occurs.
|
| 申请公布号 |
US2005154012(A1) |
申请公布日期 |
2005.07.14 |
| 申请号 |
US20050074077 |
申请日期 |
2005.03.08 |
| 申请人 |
CAI SUI X.;ZHANG HAN-ZHONG;DREWE JOHN A.;REDDY P. S.;KASIBHATLA SHAILAJA;KUEMMERLE JARED D.;OLLIS KRISTIN P. |
发明人 |
CAI SUI X.;ZHANG HAN-ZHONG;DREWE JOHN A.;REDDY P. S.;KASIBHATLA SHAILAJA;KUEMMERLE JARED D.;OLLIS KRISTIN P. |
| 分类号 |
C07D487/04;A61K31/335;A61K31/38;A61K31/395;A61K31/4155;A61K31/422;A61K31/4245;A61K31/427;A61K31/4439;A61K31/4709;A61K31/4725;A61K31/497;A61K31/506;A61K31/519;A61K31/5377;A61K31/54;A61P1/04;A61P17/00;A61P17/06;A61P29/00;A61P31/12;A61P35/00;A61P35/02;A61P37/06;A61P43/00;C07D409/04;C07D409/14;C07D413/04;C07D413/14;C07D417/04;C07D417/14;C07D471/04;(IPC1-7):A61K31/470;A61K31/443 |
主分类号 |
C07D487/04 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
|
| 地址 |
|
