发明名称 |
EPHA2 T-CELL EPITOPE AGONISTS AND USES THEREFOR |
摘要 |
EphA2 T-cell epitope agonists are provided herein. The agonists include peptides corresponding to specific fragments of human EphA2 protein containing one or more T-cell epitopes, and conservative derivatives thereof. The EphA2 T-cell epitope agonists are useful in an assay, such as an ELISPOT assay, that may be used to determine and/or quantify a patient's immune responsiveness to EphA2. The agonists also are useful in methods of modulating a patient's immune reactivity to EphA2, which has substantial utility as a treatment for cancers that overexpress EphA2, such as renal cell carcinoma (RCC). The EphA2 agonists also can be used to vaccinate a patient against EphA2, by in vivo or ex vivo methods. |
申请公布号 |
WO2005012350(A3) |
申请公布日期 |
2005.07.14 |
申请号 |
WO2004US23931 |
申请日期 |
2004.07.22 |
申请人 |
UNIVERSITY OF PITTSBURGH-OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION;MEDIMMUNE, INC.;STORKUS, WALTER, J.;KINCH, MICHAEL, S. |
发明人 |
STORKUS, WALTER, J.;KINCH, MICHAEL, S. |
分类号 |
A61K38/17;C07K14/47;C07K14/705;G01N33/50;G01N33/569 |
主分类号 |
A61K38/17 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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