发明名称 |
CYTOKINE VARIANT POLYPEPTIDES |
摘要 |
We describe modified cytokine ligand polypeptides comprising a modified amino acid sequence which is a modification of the native cytokine amino acid sequence of said ligand, wherein the native amino terminal and carboxyl terminal amino acid residues of the native polypeptide are linked, directly or indirectly, together, characterised in that said ligand is provided with alternative amino terminal and carboxyl terminal amino acid residues and further wherein at least one binding domain for said ligand's cognate binding partner or receptor complex is disrupted. |
申请公布号 |
WO2005003165(A3) |
申请公布日期 |
2005.07.14 |
申请号 |
WO2004GB02827 |
申请日期 |
2004.06.28 |
申请人 |
ASTERION LIMITED;SAYERS, JON;ARTYMUIK, PETER;ROSS, RICHARD |
发明人 |
SAYERS, JON;ARTYMUIK, PETER;ROSS, RICHARD |
分类号 |
C07K14/52;C07K14/61;C12N15/10 |
主分类号 |
C07K14/52 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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