发明名称 |
Protein-protein interaction antagonist screening libraries based upon 1,4-disubstituted naphthalenes and related scaffolds |
摘要 |
The present invention relates to 1,4-disubstituted naphthalene scaffold compounds and other closely related scaffold compounds. The present invention also relates to combinatorial libraries of such compounds. In addition, the present invention relates to a method of identifying a protein-protein interaction antagonist. The method first involves providing a compound as described herein. Next, the compound is contacted with interacting proteins of a protein-protein interaction target complex, whereby the compound is allowed to compete with the interacting proteins. Then, the activity of the compound for inhibiting formation of the protein-protein interaction target complex is measured. Finally, the compound that inhibits formation of the protein-protein interaction target complex is identified as a protein-protein interaction antagonist. Also disclosed is a method for modulating a protein-protein interaction. The method involves contacting interacting proteins of a protein-protein interaction target with a compound as described herein, whereby the protein-protein interaction between the interacting proteins is modulated.
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申请公布号 |
US2005153366(A1) |
申请公布日期 |
2005.07.14 |
申请号 |
US20040005194 |
申请日期 |
2004.12.06 |
申请人 |
HANGAUER DAVID G.;JI TAO;LEE MADISON;PRUITT STEVEN |
发明人 |
HANGAUER DAVID G.;JI TAO;LEE MADISON;PRUITT STEVEN |
分类号 |
A61K31/165;A61K31/277;C07C235/66;C07C243/28;C07C255/13;C07D249/14;C07D261/14;C07D277/18;C07D277/46;C07D285/12;C07D285/135;C07D295/185;C40B30/04;G01N;G01N33/53;G01N33/543;G01N33/68;(IPC1-7):A61K31/277 |
主分类号 |
A61K31/165 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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