发明名称 |
ASSAY FOR DETECTING CHANGES IN MITOCHONDRIAL MEMBRANE INTEGRITY AND METHOD OF USING SAME |
摘要 |
An assay for assessing the permeability of mitochondrial membranes is provided. The assay is based on enzymatic reactions that produce a detectable signal in the presence of intra-mitochondrial compounds. In some embodiments, the intra-mitochondrial compounds may be reduced and/or oxidized nicotinamide adenine dinucleotides (i.e., NADH and NAD<+>, respectively). The assay may optionally be provided in the form of a kit, and may further be useful in the discovery and interrogation of compounds that may serve to inhibit pathologic increase in mitochondrial membrane permeability, which is associated with numerous and varied mammalian disease. |
申请公布号 |
WO2005024377(A3) |
申请公布日期 |
2005.07.14 |
申请号 |
WO2004US27628 |
申请日期 |
2004.08.26 |
申请人 |
UNIVERSITY OF MARYLAND, BALTIMORE;KRISTIAN, TIBOR;FISKUM, GARY |
发明人 |
KRISTIAN, TIBOR;FISKUM, GARY |
分类号 |
G01N33/50 |
主分类号 |
G01N33/50 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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