发明名称 |
FCgamma RECEPTOR-BINDING POLYPEPTIDE VARIANTS AND METHODS RELATED THERETO |
摘要 |
The compositions and methods of the present invention are based, in part, on our discovery that an effector function mediated by an Fc-containing polypeptide can be altered by modifying one or more amino acid residues within the polypeptide (by, for example, electrostatic optimization). The polypeptides that can be generated according to the methods of the invention are highly variable, and they can include antibodies and fusion proteins that contain an Fc region or a biologically active portion thereof. |
申请公布号 |
WO2005063815(A2) |
申请公布日期 |
2005.07.14 |
申请号 |
WO2004US37948 |
申请日期 |
2004.11.12 |
申请人 |
BIOGEN IDEC MA INC.;VAN VLIJMEN, HERMAN;TAYLOR, FREDERICK, R.;GARBER, ELLEN |
发明人 |
VAN VLIJMEN, HERMAN;TAYLOR, FREDERICK, R.;GARBER, ELLEN |
分类号 |
A61K39/00;C07K16/00;G06F19/16;G06F19/18 |
主分类号 |
A61K39/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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