METHODS AND COMPOSITIONS FOR IDENTIFYING DISEASE GENES USING NONSENSE-MEDIATED DECAY INHIBITION
摘要
The invention provides compositions and methods for diagnostic and therpeutic applications of gene identification by nonsense-mediated decay inhibition (GINI). The approach allows the rapid identification of the genes and genetic lesions responsible for monogenic as well as polygenic human genetic disorders. In addition, the approach supports diagnostic typing and therapeutic selection for human cancers and other disorders arising as a result of gene mutations.
申请公布号
WO02083862(A3)
申请公布日期
2005.07.14
申请号
WO2002US11688
申请日期
2002.04.12
申请人
JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE;DIETZ, HARRY, C.;NOENSIE, ERICK;MENDELL, JOSHUA