发明名称 |
Diagnostic and therapeutic use of human maguin proteins and nucleic acids for neurodegenerative diseases |
摘要 |
The present invention discloses the differential expression of the human MAGUIN-1 and/or human MAGUIN-2 gene in specific brain regions of Alzheimer's disease patients. Based on this finding, this invention provides a method for diagnosing or prognosticating a neurodegenerative disease, in particular Alzheimer's disease, in a subject, or for determining whether a subject is at increased risk of developing such a disease. Furthermore, this invention provides therapeutic and prophylactic methods for treating or preventing Alzheimer's disease and related neurodegenerative disorders using a human MAGUIN gene. A method of screening for modulating agents of neurodegenerative diseases is also disclosed.
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申请公布号 |
US2005153295(A1) |
申请公布日期 |
2005.07.14 |
申请号 |
US20040508343 |
申请日期 |
2004.12.17 |
申请人 |
VON DER KAMMER HEINZ;HANES JOZEF;POHLNER JOHANNES |
发明人 |
VON DER KAMMER HEINZ;HANES JOZEF;POHLNER JOHANNES |
分类号 |
A61K38/00;C07K14/47;C12N15/12;C12Q1/68;G01N33/53;G01N33/567;(IPC1-7):C12Q1/68 |
主分类号 |
A61K38/00 |
代理机构 |
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