发明名称 Ceramide emulsions
摘要 Provided is a ceramide emulsion containing the following components (A), (B) and (C) and not containing an acrylic acid polymer or a phospholipid: (A) sphingosines represented by Formula (1): (wherein R<SUP>1 </SUP>represents a hydrocarbon group having 4 to 30 carbon atoms which is optionally substituted with a hydroxyl group and the like; Y represents CH<SUB>2</SUB>, CH or O; X<SUP>1</SUP>, X<SUP>2 </SUP>and X<SUP>3 </SUP>represent H, a hydroxyl group or an acetoxy group; X<SUP>4 </SUP>represents H, an acetyl group or a glyceryl group or, together with an adjacent O atom, forms an oxo group; R<SUP>2 </SUP>and R<SUP>3 </SUP>represent H, a hydroxyl group, a hydroxymethyl group or an acetoxymethyl group; groups "R"s are H or an amidino group or represent a hydrocarbon group having 1 to 8 carbon atoms which may have a substituent such as a hydroxyl group and the like; and "a" is 2 or 3), (B) an acidic compound selected from inorganic acids and organic acids having a molecular weight of 200 or less, and (C) ceramides represented by Formula (2): (wherein R<SUP>7 </SUP>represents a hydrocarbon group having 4 to 30 carbon atoms which is optionally substituted with a hydroxyl group and the like; Z represents CH<SUB>2</SUB>, CH or O; X<SUP>5</SUP>, X<SUP>6 </SUP>and X<SUP>7 </SUP>represent H, a hydroxyl group or an acetoxy group, X<SUP>4 </SUP>represents H, an acetyl group or a glyceryl group or, together with an adjacent O atom, forms an oxo group; R<SUP>8 </SUP>and R<SUP>9 </SUP>represent H, a hydroxyl group, a hydroxymethyl group or an acetoxymethyl group; R<SUP>10 </SUP>represents a hydrocarbon group having 5 to 60 carbon atoms which is optionally substituted with a hydroxyl group and the like; and R<SUP>11 </SUP>represents H or a hydrocarbon group having 1 to 8 carbon atoms which optionally have a substituent such as a hydroxyl group and the like).
申请公布号 US2005152865(A1) 申请公布日期 2005.07.14
申请号 US20050498112 申请日期 2005.03.09
申请人 YAMAMOTO YUMIKO;TANAHASHI MASANORI 发明人 YAMAMOTO YUMIKO;TANAHASHI MASANORI
分类号 A61K8/06;A61K8/36;A61K8/365;A61K8/41;A61K8/44;A61K8/55;A61K8/68;A61K31/00;A61K31/133;A61K31/164;A61P17/16;A61Q19/00;(IPC1-7):A61K7/075;A61K7/08 主分类号 A61K8/06
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