发明名称 |
METHODS OF IDENTIFYING IMMUNOREGULATORY AGENTS, IMMUNOREGULATORY AGENTS, AND USES THEREOF |
摘要 |
The present invention provides methods of identifying a substance that down-regulates or up-regulates an immune response and kits used for the identification methods. A method of this invention comprises detecting a substance that inhibits or enhances the interaction between CD26 and caveolin-1. Another method comprises detecting a substance that inhibits or enhances the interaction between caveolin-1 and Tollip. Still another method comprises detecting a substance that inhibits or enhances the interaction among caveolin-1, Tollip, and IRAK-1. The present invention also relates to immunoregulatory agents comprising a substance that down-regulates an immune response, such as siRNA against caveolin-1 or Tollip. The invention further provides immunoregulatory agents comprising a substance that up-regulates an immune response. These agents are useful for treating inflammatory diseases, autoimmune diseases, or other immune-mediated disorders. |
申请公布号 |
WO2005063170(A2) |
申请公布日期 |
2005.07.14 |
申请号 |
WO2004JP19846 |
申请日期 |
2004.12.28 |
申请人 |
TOUDAI TLO, LTD.;MORIMOTO, CHIKAO;OHNUMA, KEI |
发明人 |
MORIMOTO, CHIKAO;OHNUMA, KEI |
分类号 |
C12N15/113;G01N33/50;G01N33/68;G01N33/94 |
主分类号 |
C12N15/113 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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