| 摘要 |
<p>A carboxylic acid compound of the formula (I-a) <CHEM> wherein R is amino and the like, A is alkylene and the like, X is O, S and the like, M is arylene and the like, R<1>, R<2>, R<3> and R<4> are H, hydroxy and the like. The carboxylic acid compound of the formula (I-a) can be used for making an amide compound of the formula (I): <CHEM> wherein R, A, X, R<1>, R<2>, R<3> and R<4> are as described above and R<5> is H, alkyl and the like, m is an integer of 0-6, R<6> is an optionally substituted aryl and the like, and R<7> is H, an optionally substituted alkyl and the like, a pharmaceutically acceptable acid addition salt thereof and a pharmaceutical containing same as an active ingredient. The amide compounds exhibit superior suppressive effects on cytokines directly or indirectly involved in inflammations, such as IL-8, IL-1, IL-6, TNF- alpha , GM-CSF and the like, and are useful for the prophylaxis and treatment of rheumatic diseases, arthritis due to gout and the like.</p> |
