The present invention discloses a Gram negative bacterium in which the expression of a protein involved in LPS transport to the outer membrane is functionally downregulated such that the level of LPS in the outer membrane is decreased compared to a wild-type Gram negative bacterium. Down regulation o f Imp and MsbA proteins can result in such a bacterium. Outer membrane vesicle preparations derived from the Gram negative bacterium of the invention can b e used in vaccines to provide protection against bacterial infection.
申请公布号
CA2550927(A1)
申请公布日期
2005.07.14
申请号
CA20042550927
申请日期
2004.12.21
申请人
GLAXOSMITHKLINE BIOLOGICALS S.A.;UTRECHT UNIVERSITY
发明人
TOMMASSEN, JOHANNES PETRUS MARIA;TEFSEN, BORIS;POOLMAN, JAN;BOS, MARTINE PETRONELLA