Compounds and compositions as protein kinase inhibitors

摘要

The invention provides a novel class of compounds, pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases and disorders associated with kinase activity, particularly diseases associated with the activity of CDK1, CDK2, CDK4, CDK5, GSK3beta, Bcr-ab1, Flt-3, c-Kit, PDGFRbeta, Src, Mek1 and CK1.