| 摘要 |
A preventive or therapeutic agent for multiple risk factor syndrome containing, as an active ingredient, one or more chemical compounds selected from the group consisting of ascochlorin, ascochlorin homologues, ascofuranone and ascofuranone homologues, each of the chemical compounds having at least an olsyl aldehyde moiety, in which neither of the hydrogen atoms of the 2- and 4-hydroxyl groups are substituted; and the hydrogen atom of at least one of the hydroxyl groups is substituted by a group selected from the group consisting of (C<SUB>1</SUB>-C<SUB>15</SUB>) alkyl, (C<SUB>2</SUB>-C<SUB>15</SUB>) alkenyl, (C<SUB>1</SUB>-C<SUB>15</SUB>) alkylnyl, aryl, (C<SUB>1</SUB>-C<SUB>15</SUB>) alkylaryl; -(C<SUB>n</SUB>H<SUB>2n</SUB>)R (where n is an integer of 1 to 15 and R represents COOR' which substitutes for any one of n carbon atoms where R' is H or (C<SUB>1</SUB>-C<SUB>15</SUB>) alkyl), (C<SUB>1</SUB>-C<SUB>15</SUB>) alkylcarbonyl, arylcarbonyl, aryl(C<SUB>1</SUB>-C<SUB>15</SUB>)alkyl, aryl (C<SUB>1</SUB>-C<SUB>15</SUB>) alkylcarbonyl, -C(-O)(CH<SUB>2</SUB>)<SUB>1-15</SUB>COOH, 2-pyridylcarbonyl, nicotinoyl, isonicotinoyl, toluenesulfonyl, carbamoyl, carbamoyl substituted by one or two (C<SUB>1</SUB>-C<SUB>6</SUB>) alkyls, amino, amino substituted by one or two (C<SUB>1</SUB>-C<SUB>6</SUB>) alkyls, aryloxy (C<SUB>1</SUB>-C<SUB>15</SUB>) alkyl optionally having a halogen on the ring, and aryl having a (C<SUB>1</SUB>-C<SUB>6</SUB>) alkoxy or a (C<SUB>1</SUB>-C<SUB>6</SUB>) alkoxy on the ring.
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