| 发明名称 |
MODULATORS OF ATP-BINDING CASSETTE TRANSPORTERS CONTAINING CYCLOALKYL OR PYRANYL GROUPS |
| 摘要 |
The present invention provides compounds of Formula (I) useful as modulators of ABC transporter activity, or a pharmaceutically acceptable salt thereof, wherein R<B>, n, B, R<C>, R<D>, R<E>, A, and Z are described generally and in classes and subclasses below. The present invention also provides pharmaceutical compositions, methods and kits associated with Formula (I), useful for as modulators, and for the treatments of disease and disease conditions associated with ABC transporter proteins. |
| 申请公布号 |
WO2005035514(A3) |
申请公布日期 |
2005.07.14 |
| 申请号 |
WO2004US33367 |
申请日期 |
2004.10.08 |
| 申请人 |
VERTEX PHARMACEUTICALS INCORPORATED;HADIDA RUAH, SARA S.;SINGH, ASHVANI K.;MILLER, MARK T.;HAMILTON, MATTHEW;GROOTENHUIS, PETER D.J. |
发明人 |
HADIDA RUAH, SARA S.;SINGH, ASHVANI K.;MILLER, MARK T.;HAMILTON, MATTHEW;GROOTENHUIS, PETER D.J. |
| 分类号 |
A61K31/00;A61K31/335;A61K31/38;A61K31/40;A61K31/41;A61K31/435;A61K31/495;A61K45/06;C07C233/11;C07C233/22;C07C233/60;C07C233/65;C07C233/73;C07C235/34;C07C235/46;C07C235/48;C07C307/00;C07C311/16;C07C311/17;C07C323/60;C07D209/42;C07D213/82;C07D215/54;C07D215/56;C07D217/26;C07D231/14;C07D231/56;C07D237/28;C07D261/20;C07D307/68;C07D307/85;C07D307/87;C07D333/32;C07D333/70;C07D407/12 |
主分类号 |
A61K31/00 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
|
| 地址 |
|
