Heterocyclic inhibitors of MEK and methods of use thereof

摘要

Disclosed are compounds of the Formula I and pharmaceutically acceptable salts and prodrugs thereof, wherein R¹, R², R⁷, R⁸ and R⁹, W, X, Y and Z are as defined in the specification. Such compounds are MEK inhibitors and are useful in the treatment of hyperproliferative diseases, such as cancer and inflammation, in mammals, and inflammatory conditions. Also disclosed are methods of using such compounds in the treatment of hyperproliferative diseases in mammals and pharmaceutical compositions containing such compounds.