| 摘要 |
This invention relates to the delivery of medicines, macromolecules, or other treating materials to tissues and/or fluids that are to be injected or placed within a human or animal body. The invention describes a method of introducing a treating material to fluids ex corpora using a malleable fracture stabilization device with micropores for directed drug delivery (U.S. Pat. No. 5,466,262) into which a medicine has been incorporated, an apparatus for managing macromolecular distribution (U.S. Pat. No. 5,653,760) that has been coated with a treating material, or any surface to which has been affixed a treating material. The invention describes the use of a disposable housing that contains a semipermeable membrane to which a treating material has been affixed. The invention teaches the use of a dialysis membrane to which heparin or other anticoagulant has been affixed, thereby substantially preventing thrombosis on the membrane while limiting the amount of heparin that must be given systemically. Furthermore, the present invention provides a new and useful mechanism to deliver a treating material directly into the intravenous line from a pre-labeled vial, at a precise rate, and in a minimum volume of fluid. This invention can also be used to deliver treating materials directly to cells and tissues at a defined rate, while at the same time permitting small metabolites and other small toxins to wash away. |
